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The underlying mechanisms may involve factors with sex-specific roles in CVD, such as testosterone

10.2174/13816128113199990421 100 SeiwerthS.RucmanR.TurkovicB.SeverM.KlicekR.RadicB.et al (2018)

While thats its official use, its benefits go far beyond a narrow clinical application

Ventorp F, Bay-Richter C, Nagendra AS, Janelidze S, Matsson VS, Lipton J, et al

ACE2 structure/function ACE2 is an essential counter-regulatory carboxypeptidase of the hormonal RAAS, a vital regulator of blood volume, systemic vascular resistance, and thus the CV/circulatory homeostasis 292