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Because semaglutide has a 7-day half-life, symptoms can last 3 to 7 days
Mechanistically, it has multiple hydroxyl groups that hydrogen-bond to water
NICE guidance specifies use for people with a BMI of at least 35 kg/m (or 30 kg/m with weight-related comorbidities) who have been referred to specialist services
The goal is not to suffer through side effects, but to find the dose that produces results while remaining tolerable
Moreover, the management of side effects is a crucial aspect of any medication, and semaglutide is no exception
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