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The proposed mechanism for the inhibitory effect on MM growth is through the induction of the intrinsic apoptotic pathway and the inhibition of cell cycle progression in the G0/G1 phase (Rogers et al., 2020)
Its 3-letter sequence, Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Asn-His (31 residues as tabulated with N-terminal modification), features a single methionine that analysts should note as a potential oxidation site during method development, alongside multiple basic residues (Arg, Lys, His) that dominate its charge state envelope in positive-mode ESI-MS
Gold SM, Voskuhl RR (2009) Estrogen and testosterone therapies in multiple sclerosis
The inclusion of both reference and clinical strains enhances the translational relevance of the study and allows assessment of antimicrobial efficacy under both standardized and real-world clinical conditions
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