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The condition is associated with significant cardiovascular, renal, and neuropathic complications

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In the brain, Hv1 is selectively highly expression in microglia, becoming one of the major ion channels in resting microglia [18, 19]

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Any suspected adverse reactions can be reported through the MHRA Yellow Card scheme

Third, it focuses attention on the tolerability challenge: greater potency appears to come with a higher side effect burden, and the field must determine how to preserve efficacy while improving patient retention [5]