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The trial enrolled 281 participants across 42 research and healthcare centers in the United States, randomized to once-weekly subcutaneous retatrutide (0.5, 4, 8, or 12 mg), once-weekly subcutaneous dulaglutide 1.5 mg (active comparator), or placebo, over a 36-week treatment period
Who Is at Higher Risk for Mood Changes on Tirzepatide and GLP-1 Therapy People with a history of major depressive disorder, bipolar disorder, prior suicidal ideation, or unstable psychiatric conditions face a higher risk for psychiatric adverse events on any weight loss drug
If more than five days have passed, skip the missed dose and wait for your next scheduled injection
Your consultation includes a discussion of your goals, medical history, lifestyle factors, and treatment options
196 For people who are unable to attain weight-related health improvements with behaviour modifications and pharmacotherapy, or unable to sustain weight loss after treatment discontinuation, referral to specialised care is generally required
Topiramate (available as Topamax) : Topiramate is an anticonvulsant drug that has demonstrated weight loss effects in certain patients
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