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The FDA's stated position is that compounded drugs should generally only be used when a patient's medical needs cannot be met by an FDA-approved drug

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12 Furthermore, it suppresses ghrelin, the hormone primarily responsible for appetite stimulation

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In a phase 2 clinical trial targeting obese individuals without type 2 diabetes (T2D), retatrutide dosed at 1 to 12 mg resulted in up to 24.2% weight loss over a 48-week treatment period, compared to 2.1% in the placebo group, and demonstrated a dose-dependent effect