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In addition, GLP-1 RAs protect against mitochondrial dysfunction, preventing the release of cytochrome c and stabilizing mitochondrial membranes, thereby inhibiting apoptosis
The physiological effects of GLP-1 RAs are multifaceted
Rapid weight loss can stress joints, connective tissue, and muscle
As an example of a combined GLP-1 + FIM intervention, eligible patients could receive both GLP-1 therapy and a FIM intervention emphasizing foods to support weight maintenance, reduce side effects, minimize loss of muscle and bone mass, and promote nutrient adequacy
Mult Scler Relat Disord 9:8090
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