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It was originally developed by researchers at the University of Arizona as part of a programme to identify stable, receptor-selective melanocortin analogues suitable for photoprotection research
PEW tends to occur as patients approach end-stage kidney failure (17,18) and inauguration of chronic dialysis treatment is associated with an improvement in PEW (19)
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At the cellular level, IAA causes neurotoxicity by inducing BBB disruption, neuroinflammation, and apoptosis
B 879 , 13081315 (2011)
Additionally, it may have potentially lowered the expression of urea cycle enzymes, restored nitrogen balance, and hypothetically normalized or improved the nitrogen contents in organs
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