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Participants were recruited from the Bariatric Clinics at UCLH and Homerton University Hospital
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Functions of DNA methylation: islands, start sites, gene bodies and beyond
In the pancreatic alpha cell, proglucagon is processed by prohormone convertase 2 (PC2), resulting in the generation of glucagon and the so-called major proglucagon fragment, while in L cells, proglucagon is processed by PC1/3 resulting in the generation of GLP-1, among other products [16] (Fig
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