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Participants were randomly assigned to receive either placebo or amycretin, as a single ascending dose (0.3 mg, 0.6 mg, or 1.0 mg) or as once-weekly multiple ascending doses, escalating from 0.3 mg up to a maintenance dose of 60 mg (over 36 weeks), 20 mg (over 36 weeks), 5 mg (over 28 weeks), or 1.25 mg (over 20 weeks)
AndreozziFRacitiGANigroCManninoGCProcopioTDavalliAMet al
7 (download XLSX Statistical source data for Fig
Louis, MO, United States), 40 g/ml Proline (Sigma-Aldrich), 50 g/ml ascorbic acid (Sigma-Aldrich) and 10 ng/ml TGF-1 (Peprotech, Rocky Hill, NJ, United States)
Am Heart J 2024;267:1-11
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