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This result warrants caution: oral bioavailability of hexapeptides is generally very low due to gastrointestinal degradation and poor intestinal absorption, and the finding has not been widely replicated or supported by pharmacokinetic data confirming systemic absorption at meaningful levels

Drug Metab Dispos 2020;48:326-36

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The spent variant arises after the molecule has performed its function

A crossover design was chosen for several key reasons