Feeling tired while on semaglutide GLP-1, a medication used for type 2 diabetes and obesity, can stem from multiple reasons
In addition, it is an important coenzyme in the metabolism of carbohydrates, lipids, and proteins (11, 16, 18, 59)
Opioid Use Disorder Penn State Study of Semaglutide for OUD in Combination with Methadone or Buprenorphine Status: Recruiting 200-person study of semaglutide in combination with methadone or buprenorphine
An adjunct-to-lithium trial also shows positive results with tamoxifen 80 mg + lithium 1.01.2 mEq/L being superior to placebo adjunct (Amrollahi et al., 2011)
it affects other organs too
For semaglutide, one could expect a different side-effect profile for the oral versus the subcutaneous formulation