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They found that glutathione was significantly lower in several key brain areas in the participants with first-episode psychosis, lending support to the concept that oxidative stress in the central nervous system plays an important role in its pathophysiology. Authors of the third paper reported that participants with first-episode psychosis performed significantly worse on cognitive tests compared with controls
Future studies that include people with mental health conditions will be essential, say De Giorgi and Mansur, who are both actively researching the drugs' mental health effects
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