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Inhibition of cellular autophagy in proximal tubular cells of the kidney in streptozotocin-diabetic and uninephrectomized rats
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However, despite previous reports on the potential advantage posed by GLP1-based multi-agonists in the management of obesity and metabolic disease, as recently exemplified by the dramatic body weight-lowering actions of the GLP1/GIP dual agonist, tirzepatide 47 , to our knowledge, no study has addressed to date the pharmacological characterization of GLP1-based unimolecular multi-agonists for management of reproductive and metabolic alterations of PCOS, using suitable preclinical models, as pre-requisite for their application in clinics
When paired with a diet built on whole foods, hydration, and steady antioxidant intake, its effects tend to last longer and deliver more visible, meaningful improvements
NgSKWoodJPMChidlowGHanGKittipassornTPeetDJet al
Free Radical Biology and Medicine , 67, 396-407
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