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The oxidative stress-induced lipid peroxide is a significant mechanism in the pathogenesis of depression, with the accumulation of lipid peroxidation (LPO) contributing to neuronal cell death and dysfunction (Prust et al., 2020)
Subsequently, cystathionine is cleaved, leading to Cys production (Finkelstein, 1990)
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In recent years, polyphenolic compounds derived from pomegranate have been investigated as dietary supplements aimed at alleviating exercise-induced fatigue (52), with studies highlighting the anti-inflammatory properties of pomegranate extracts
Experimental investigations have reported increased expression of angiogenic mediators and enhanced vascularization in various laboratory models
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