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Significant weight loss particularly reduction of visceral fat is associated with improvements in testosterone levels in men with obesity-related hypogonadism, as visceral fat drives conversion of testosterone to oestrogen
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Structured history: timing, GI symptoms/dehydration, menopause/GSM risk, meds incl
The Phase 2 dose-finding trial (N=338), published in the New England Journal of Medicine in 2023 (DOI: 10.1056/NEJMoa2301972), randomized participants with obesity (BMI 30-50) to retatrutide at doses ranging from 0.5mg to 12mg weekly or placebo over 48 weeks
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