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In addition to the neuropharmacological effects of GIPR antagonism, we also demonstrate that CNS GIPR KO prevents body weight gain under HFD challenge, supporting the role of CNS GIPR as a primary driver of body weight differences seen in the whole-body GIPR KO mouse 41
Separate direct evidence from theory
Separate experiments showed the peptide preserved blood flow in ischemic tissues by influencing endothelial NOS (eNOS) activity [5]
Tirzepatide primarily works by helping regulate appetite, fullness, and blood sugar levels
Key Points Weight regain after bariatric surgery is a frequently occurring clinical challenge
GHK-Cu is a reasonable option for those with retinoid intolerance or as a complementary agent, but it should not be marketed as a retinoid replacement
