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Marx N, Federici M, Schuett K, Mueller-Wieland D, Ajjan RA, Antunes MJ, et al

A 2018 study showed that NAC may be helpful in the treatment of those with bipolar depression while a 2016 study suggests that NAC may be helpful when taken in addition to routine medications used to treat schizophrenia

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Ingested creatine phosphate, which is also abundant in meat, is hydrolyzed extracellularly by alkaline phosphatases (synthesized and released by enterocytes) into creatine and phosphate before intestinal absorption (Fernley 1971)

Affects roughly 20-30% of users, with the highest incidence during dose escalation phases

However, certain medications can make a vitamin B deficiency more likely