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Step 4 Account for solvent compatibility and administration route

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When insulin sensitivity improved through exercise or bariatric surgery, NNMT levels in adipose tissue fell suggesting NNMT activity tracks with metabolic state rather than being a passive marker

In conclusion, this study demonstrated that intra-articular injections of AOD9604 improved cartilage health and functional recovery in a rabbit OA model

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It is more relevant for larger animal models (rabbits, minipigs, dogs)