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In line with these results, in the randomised, placebo-controlled SUSTAIN 5 trial of once-weekly subcutaneous semaglutide as an add-on to basal insulin, the insulin dose was significantly decreased from baseline with both the semaglutide 0.5 and 1.0 mg doses compared with placebo [38]
Ghrelin increases appetite and food intake by directly acting on the ARC of the hypothalamus [38]
Its popularity has also led to growing interest in possible side effects
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Related Reading : How Semaglutide Works: Understanding the Mechanism Behind Its Weight Loss Effects 3
Week 8+: Sustained Progress At your target maintenance dose, hunger and cravings are well managed
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