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For men who do not respond to oral medications, second-line treatments include vacuum erection devices, intracavernosal injections (alprostadil), intraurethral therapy, or penile prosthesis surgery
Rat and gerbil studies have demonstrated that intraperitoneal NAC administration protects against oxidative damage induced by acrolein, peroxynitrite, hydroxyl radicals and 3-nitropropionic acid while increasing GSH levels in the brain and synaptosomes (119123)
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The exact timing depends on the injury type, baseline tissue condition, and individual response rate