Acylcarnitine assay Acylcarnitines were extracted from either 10 l of whole liver homogenate, 50 l of plasma, 50 l brain parenchyma, 50 l cerebrovasculature (timepoint study), 60 l of cerebrovasculature (cerebrovascular uptake study) or 100 l of brain homogenate (all homogenized as described above) and spiked with 5 l of acylcarnitine internal standard (IS) mix containing 12 M TMAO-d9 (Cambridge Isotope Laboratories, Inc., CIL), NSK-B (CIL) and NSK-B-G1 (CIL) at the beginning of the extraction process
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Tirzepatide , a dual GIP/GLP-1 agonist, shows intermediate rates
But tirzepatide consistently beat GLP-1-only medications despite activating the GLP-1 receptor less aggressively than semaglutide, which meant something else was contributing to the superior results
doi: 10.1007/s10815-017-0992-5 204 AminAFShaabanOMBediawyMA