In Japan it has been approved specifically as a diagnostic agent (pralmorelin) for growth hormone deficiency testing, which is a different and narrower category than therapeutic approval
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In particular, urinary 8-hydroxy-2-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, has been found higher in NS workers compared to day shift (DS) workers, although its levels may vary depending on timing relative to work and sleep periods 65,66,67,68
16 CampisiG.BizzocaM
Board-Certified Gastroenterologist
World Journal of Hepatology, 17(2)