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Powell-Wiley TM, Poirier CP, Burke VCLE, Desprs JP, Gordon-Larsen P, Lavie CJ, et al
How peptide immunotherapy achieves tolerance The mechanisms include induction of specific T-cell anergy (functional inactivation of allergen-reactive T-cells), differentiation of naive T-cells into regulatory T-cells, immune deviation (shifting the Th2/Th1 ratio toward Th1), and allergen-specific Th2 cell deletion
Recent evidence suggests that episodes of ketoacidosis can also occur [69], and it might be of particular concern among insulin-deficient individuals, including those with longstanding T2D, T1D, or latent autoimmune diabetes in adults (LADA) [70]
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