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Eur J Hum Genet

Staff cited inadequate substance characterization, uncertain product quality, insufficient evidence of effectiveness for ulcerative colitis, sparse human safety data, and unresolved risks such as immunogenicity, aggregation, impurities, and long-term exposure

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Investigators have studied the compound in combination with other research molecules, in biomaterial-integrated delivery formats, and in cell-type-specific contexts that broaden the mechanism understanding documented in foundational papers

It provides ongoing competitive inhibition that requires maintained presence

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