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As shown on the right panel, aspirin irreversibly inhibits COX activity by acetylation of a serine residue in the active site for COX (SER 529 in COX-1 & SER 516 in COX-2)
Like rifampin, aminoglutethimide substantially reduced tamoxifen AUC (by 73%), and the effect of aminoglutethimide on endoxifen AUC (93% decrease) was even greater than found for rifampin in the study cited above
Whereas ACG Glutathione is rapidly absorbed &
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