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To compete with the upcoming generics, Novo Nordisk received Health Canada approval on December 22, 2025, for two new branded products, Plosbrio and Poviztra

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Cases of death by rupturing, bursting, or runoff were considered censored

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Novo Nordisks injectable semaglutide is also in Phase 3 development for T1DM, with and without comorbidities

Eli Lilly said the oral GLP-1 pill has been shown to reduce hemoglobin A1C levels -- a blood test that shows average blood sugar levels over two to three months -- by an average of 1.3% to 1.8% in people with diabetes