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More than a century ago, patients would get worse and worse until they died
Vitamin B12 deficiency can occur due to dietary restrictions (vegetarian or vegan diets), absorption issues (pernicious anemia or gut disorders like celiac disease or Crohns disease), age-related changes in elderly patients, or long-term use of certain medicines
a larger intramuscular (in the muscle) 25 gauge 1 inch needle for maximum intramuscular benefit
NNMT consumes S-adenosylmethionine (SAM) as a methyl donor, so inhibiting NNMT could theoretically increase SAM availability for other methylation reactions
So, for a 1000 mcg dose, you give 1 mL of the solution
Allergy risk to cobalt or preservatives (rare) Energy improvement: 24-72 hours Reticulocyte response: 3-5 days Neurological improvement: Weeks to months Hematological normalization: 4-8 weeks Maximum nerve repair: Up to 1 year Injection site reactions (15-20%) Mild diarrhea (initial doses) Itching/eczema (cobalt sensitivity) Transient anxiety (overstimulation) Headache (usually resolves quickly) Serious reactions are extremely rare
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