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Lancet 2023;402:613-26.PubMed 141

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Further study revealed that in both anti-PD-1-alone and anti-PD-1 plus ipilimumab-treated patients, compared with nonresponders, responders had markedly greater densities of CD8 + T cells in proximity to PD-L1-expressing cells (e.g., melanoma cells), which was associated with enhanced progression-free survival (PFS) for both therapeutic approaches [180, 181]

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It has been revealed that thyroid cell lines that express both BRAF and RET/PTC can provoke genes that encode immune system response molecules, such as chemokines, which are pivotal for the early stages of HT lymphocytic infiltration