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Bile-derived organoids from patients with primary sclerosing cholangitis recapitulate their inflammatory immune profile
This relationship has also shown that GSH depletion impairs dendritic cell mediated T-cell activation, further hindering immune response (Kim et al., 2007)
Immunosenescence is another crucial factor in aging, where the secretion of pro-inflammatory cytokines, chemokines, proteases, and growth factors affects neighboring cells, weakening the immune systems resistance to tumors and pathogens, increasing the risk of autoimmune diseases, and leading to chronic inflammation 32
It initiates rapid repair by enhancing keratinocyte and fibroblast migration, stimulating angiogenesis, and restoring tissue integrity
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