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[5] In the 1950s IGF1 was called "sulfation factor" because it stimulated sulfation of cartilage in vitro, [6] and in the 1970s due to its effects it was termed "nonsuppressible insulin-like activity" (NSILA)

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[8] Similarly, patients with gout or hyperuricemia should avoid high niacin intake, as niacin (even in nicotinamide form) can raise uric acid levels and potentially trigger gout flares