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Depending on the ligand-protein interaction, this may involve competitive elution, pH shift, or denaturation
In hematologic malignancies and rheumatoid arthritis, high histidine enhanced methotrexate (MTX) efficacy by diverting tetrahydrofolate toward histidine catabolism, thereby lowering the MTX dose required for cytotoxicity 79,80
Collectively, our findings not only identify a genetic master regulator of SAA metabolism, but also demonstrate that HNF4-mediated transsulfuration is a key determinant of sensitivity to methionine/cystine restriction in liver cancer
doi:10.1042/bj2860383
Researchers position glutathione alongside NAD+ in mitochondrial redox studies, examining the intersection of the glutathione antioxidant system and NAD+/NADH cycling as complementary indices of cellular energy and oxidative stress status
Levels in plasma fall with age, and that finding is what drove most of the research that followed
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