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Methods: At a large, diverse health system, we conducted a three-part study: 1) a pre-intervention PCP survey to ascertain nonalcoholic fatty liver disease (NAFLD) knowledge and practice patterns, 2) an intervention implementing a FIB-4 risk-stratification referral algorithm in primary care, and 3) a post-intervention PCP survey

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Interestingly, while this study discovered that CHAC1/BOTCH-mediated regulation of GSH levels controls development, other studies suggest its developmental role is primarily based on the inhibition of NOTCH1 signaling (Yadav et al., 2019)

Proof-of-concept studies using CLDN1-specific mAbs as a single agent reveal CLDN1 as an innovative therapeutic target for advanced CCA

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It is also used for brain and nerve cell development, and brain function