doi: 10.1038/nm.4394 116 SuribenRChenMHigbeeJOeffingerJVenturaRLiBet al
An increased delivery of fatty acids to skeletal muscle, as well as diminished mitochondrial oxidation, results in increased intracellular content of fatty acid metabolites such as diacylglycerol (DAG), fatty acyl-CoAs, and ceramides
Nutrients 14 , 690 (2022)

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Compared to CJC-1295/Ipamorelin (position 4 in this list), sermorelin has a shorter half-life and a smaller existing evidence base, but its long clinical track record and intact feedback mechanism make it a lower-risk choice for those new to peptide-based hormone support
This feedback mechanism suggests the peptide may help prevent excessive tissue growth while still promoting repair