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Factores internos, como la gentica y los cambios hormonales, juegan un papel importante, pero factores externos como el tabaco, la contaminacin, la dieta, el estrs o la exposicin solar, as como procesos biolgicos como la glicacin (el exceso de azcar), la oxidacin y la inflamacin , contribuyen enormemente al envejecimiento prematuro

Inhibit high-voltage-activated calcium currents