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The NICE criteria are as follows: NICE recommends GLP-1 analogues or Tirzepatide (Mounjaro) for the treatment of adults with type 2 diabetes alongside diet and exercise when diabetes is insufficiently controlled, only if: triple therapy with metformin and 2 other oral antidiabetic drugs is ineffective, not tolerated or contraindicated, and a person has a body mass index (BMI) of 35 kg/m2 or more, and specific psychological or other medical problems associated with obesity, or a person has a BMI of less than 35 kg/m2, and: Insulin therapy would have significant occupational implications, or Weight loss would benefit other significant obesity-related complications
Sep 9 2020;370:m3222
This depends on their B12 level and treatment needs
Ill try to be optimistic where the data warrant it, but also clear about what remains uncertain
These substances mix easily with water for the same reason that ethanol mixes easily with water
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