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Unfortunately, those financial incentives are harmful
Transcriptional profiling studies further reveal that astrocyte subpopulations adopt divergent states ranging from neuroprotective to neurotoxic phenotypes in neurodegeneration, further underscoring the importance of astrocytic heterogeneity 40,41
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GOT1 knockout combined with cysteine depletion by erastin or IKE showed potent antitumor effects against these cells by reducing GSH and increasing ferroptosis 66
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