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Nat Commun 15 , 6941 (2024)
Understanding how to transition safely between oral and injectable GLP-1 medications matters for maintaining therapeutic drug levels and minimizing side effects
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IHTG, intrahepatic triglyceride content
The effect of retatrutide on bone density is also yet to be seen, although other GLP-1s have been shown to cause a decrease in bone density proportional to weight loss
Studies have shown that semaglutide upregulates the expression of ITPR1 and ADCY5 in CRC by activating the GLP-1 receptor, which, in turn, inhibits the motility of CRC cells [88]
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