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The findings demonstrate that PRP could effectively inhibit nicotine-induced autophagy in gingival fibroblasts, offering insights into its possible use as a therapeutic tool for managing periodontitis in smokers

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Melanotan 1, which is a superpotent melanocortin, is designed to resist enzymatic breakdown, prolonging its duration of action at the MC1R compared to natural a-MSH

This dysbiosis further impairs barrier function, creating a self-perpetuating cycle that exacerbates inflammation[51]