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As with many drugs, you get the desired effect, but you also get undesirable side effects

Since the primary, if not exclusive, source of GLP-1 in the CSF are brainstem GLP-1 neurons (and not GLP-1 from the circulation 3 ), this suggests that CSF-contacting neurons are regulated by the overall activity of brainstem GLP-1 neurons

Psychiatry 108, 110151

However, it is not possible to selectively inhibit DYRK1A expression

Tirzepatide (Mounjaro) dual GIP/GLP-1 receptor agonist) 3,4 3,4 Tirzepatide is a first-in-class dual GIP and GLP-1 receptor agonist that produces superior weight loss compared with selective GLP-1 receptor agonists, through: Enhanced appetite suppression via dual receptor activation

As glucose levels fall and your insulin needs drop, GLP-1 agonists stop stimulating the production of the hormone