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Clinical Efficacy at Each Dose In the SUSTAIN program, semaglutide 1.0 mg reduced HbA1c by 1.5% to 1.8% across trials, with weight loss ranging from 4.5 kg to 6.5 kg at 30 to 56 weeks [3]

Structured exercise can help, but only if it's consistent and challenging enough to offset the metabolic slowdown

In regard to incidence of hypoglycemic events, GLP-1RA added to SGLT2i showed a similar incidence as SGLT2i (RR = 1.43

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doi: 10.1016/S1474-4422(18)30403-4 8 Grabska-KobyeckaI.SzpakowskiP.KrlA.Ksiek-WiniarekD.KobyeckiA.GbiskiA.et al

But what really blew my mind was my bloodwork at the six month mark