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However, up to 10% undergoes bioactivation to N -acetyl p -benzoquinone imine (NAPQI), a highly reactive electrophile, which is known to covalently bind to nucleophilic centers, including cysteine thiols in liver proteins (see Figure 1) (Jollow et al., 2015)
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On the contrary, search in Candida Genome Database with BLAST using the sequence of the human regulatory subunit failed to detect any similarities indicating that the regulation C
Following an oral dose, NAC absorbs rapidly, reaching its peak plasma concentration within 1 to 2 hours, and has a relatively short terminal half-life of approximately 5.5 to 6.25 hours
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