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A practical way to read the two cadences together: the weekly 5-on/2-off rhythm is a fine-grained pause aimed at short-term receptor sensitivity, while the 812-on / 4-off macro-cycle is the coarse-grained pause aimed at the whole axis
Nabwera HM, Espinoza JL, Worwui A, Betts M, Okoi C, Sesay AK, Bancroft R, Agbla SC, Jarju S, Bradbury RS, Colley M, Jallow AT, Liu J, Houpt ER, Prentice AM, Antonio M, Bernstein RM, Dupont CL, Kwambana-Adams BA
What this means for dosing calculations: the clinical trial protocols use fixed escalation schedules with specific dose targets (typically 8mg or 12mg maintenance)
Bull IACFS/ME
long-term, a good diet will help sustain them
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