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Common side effects include gastrointestinal symptoms like nausea, vomiting, diarrhea, and constipation, as well as hypoglycemia and injection site reactions
In humans there have been mutations identified in prohormone convertase 1/3 (PC1/3) and carboxypeptidase E (CPE), as well as in the -MSH degrading enzyme prolylcarboxypeptidase (PRCP) that are associated with energy imbalance and a propensity for obesity
To make matters more complicated, some breast cancer treatments such as hormonal therapy can also cause weight gain
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Research published in Pharmacy and Therapeutics suggests patients with obesity can lose at least 5 percent of their body weight after using Contrave for 12 weeksand as much as 11.5 percent after 56 weeks
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