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Again, the copper uglies are rare, but its something to be cautious about

Research presented at the American Academy of Orthopaedic Surgeons meeting in March 2026 linked GLP-1 use to nearly double the risk of bone density issues over five years

The molecular mechanisms of the neuroprotective effects of GLP-1R agonists include signaling pathways such as ERK signaling, PI3K signaling, RhoA activity, MAPK/NF-B signaling, and the Epac/Akt pathway

Studies indicate dual (OR = 3.258) or triple (OR = 8.226) anti-obesity therapy substantially elevates risk potential compared to monotherapy

If you have severe, persistent symptoms, see your doctor for evaluation

The SELECT trial also demonstrated cardiovascular risk reduction benefits