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Notably, treatment with GABA and specific interventions using DSIP-CBBBP and DSIP markedly decreased immobility times compared to the model group, suggesting their effectiveness in mitigating depressive-like behaviors

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GLP-1 analogs with anti-inflammatory properties may modulate this pathway, influencing the balance between neuroprotective and neurodegenerative metabolites, which is vital given the pathway's link to various neurological and psychiatric disorders, including depression