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It is based on the different product
semaglutide is a GLP-1 incretin peptide studied for appetite and insulin effects
doi: 10.1111/bph.v174.7 20 ZhuBGongNFanHPengCSDingXJJiangYet al
Compared to endogenous GLP-1 and glucagon, retatrutide demonstrates lower potency at GLP-1 and glucagon receptors but substantially higher potency at the human GIP receptor a pharmacological profile deliberately engineered to balance efficacy with tolerability
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