Even safety data on TB-500 (synthetic TB4) is relatively scarce, with only a few studies reporting the potential side effects of its systemic application: In a 2010 study in 10 participants, TB4 caused occasional mild to moderate symptoms like headache and dizziness but no serious reactions or toxicities, even at doses up to 1260mg, administered daily for up to two weeks
SARM1 activation triggers axon degeneration locally via NAD+ destruction
A parallel study of BFKB8488A in type 2 diabetes patients recapitulated improvements in HDL-cholesterol, triglycerides, and adiponectin, but did not demonstrate improvements in HbA1c, fasting glucose, or fasting insulin (302)
Schedule: Subcutaneous injections 5 days per week (or 3/week) for 812 weeks, optionally extended to ~16 weeks
When used as a suppository, this product requires 15-20 minutes retention to ensure the complete absorption of the bioactive ingredients
GeLSadeghiradBBallGDCda CostaBRHitchcockCLSvendrovskiAet al