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Tirzepatide (Mounjaro) is a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist currently licensed for diabetes in the UK
In the SURPASS-2 trial, patients with obesity and T2D who received tirzeapatide (5 mg weekly) achieved greater HbA1c and body weight reductions than those receiving semaglutide (1 mg weekly) during the 40 week study (64) despite comparable putative GLP-1R occupancy at these doses (47)
Ramos-Casals, M
Who Can Use Wegovy
El Beshlawy, A., Mohtar, G., Abd El, Ghafar E., Abd El Dayem, S
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