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Excessive iron levels can generate produce ROS via the Fenton reaction, activating various intracellular signaling pathways that enhance bone absorption and inhibit bone formation, thereby contributing to osteoporosis

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10.1038/s41589-020-0472-6 332 urK

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In another study, the whole transcriptome analysis of BFH12 cell lines co-treated with curcumin and AFB1, the finding purported that curcumin abated the inflammatory responses and improved antioxidant enzymes in AFB1-treated cells (424)